Day 1 :
University of Turin, Italy
Keynote: Salivary AGEs as novel biomarkers of risk factors in diet-related diseases: Preliminary results of the EU SALIVAGES Network
Time : 09:20-09:55
Massimo Collino is Professor of Pharmacology and Toxicology, Dept. Drug Science and Technology, University of Turin (Italy). He is author of 86 full papers published in international journals with Impact Factor; Citations: 1886 total citations h-index: 25. He is the European Coordinator of the European Project “Innovative Technological Approaches for validation of Salivary AGEs as novel biomarkers in evaluation of risk factors for diet-related diseases”
Advanced Glycation End Products (AGEs) are reactive compounds deriving from glycoxidation reactions between the amino groups of proteins and reducing carbohydrates. Recent findings convincingly demonstrate that Advanced Glycation End Products (AGEs) are modifiable by diet and reflect changes in healthy state. The multidisciplinary project SALIVAGES, granted by the Eupean ERA-HDHL programme, focuses on the identification and validation of non-invasive strategies for monitoring AGEs in the saliva as early and easily accessible biomarkers that are modulated by diet and that potentially indicate a change in health status and/or the risk of developing diet-related diseases. The scientific network involves five different European countries: ITALY (University of Turin), SPAIN (University of Oviedo), IRLAND (National University of Ireland Galway), ROMANIA (University of Cluj-Napoca), GERMANY ((Technische Universität Dresden). Preliminary data based on the integration of preclinical biological and molecular studies, analytical and food chemistry, information technologies, and glycomic analyses will be illustrated and discussed.
Overall, the expected results will contribute to create a paradigm shift and reveal new scientific, technological and scholarly horizons in the identification of non-invasive strategies for monitoring biomarkers that are modifiable by diet and reflect either a healthy state, or its transition towards diet-related disease.
University of Koblence-Landau, Germany
Time : 09:55-10:30
Bernhard Mann has completed his MA (Social Science) in Erlangen-Nuernberg, his PhD (Social Gerontology) in Kassel and his MPH (Public Health) at the Medical University of Hannover. He was Adjunct Professor and Full Professor of Health and Social Management at Universities and Universities of Applied Sciences in Germany. His scientific interest is the psycho-social structure of the quality of life. He got international experiences in India, Japan, Mexico, Israel, Great Britain, France etc..especially in the context with basic education by Mahatma Gandhi.
The demographic chance of the human population is globally. The number of elderly is growing: Year 1988 – 416.000.000 are 60+. Year 2025 – 806.000.000 (72 % in developing countries). As well as the life expectation of adult handicaps is increasing too. In FRG, 60+ seriously handicapped with 100 % by nearly 800 000. Familiy care for the handicaps could not be guaranteed. Parents are stressed, getting ill or come to the end of life. A system of care for the adult handicaps will be very important. They have to cope with cumulative problems such as physical, psychological and social straints. This phenomenon is known as multiple jeopardy. The question will be how to create a valuable life for an indivdual in order to improve the capabilities. Systems for care of the elderly cannot be transfered easily among countries, as the WHO approach is told. A scientific way about prevention and health promotion gives Armatya Sen (novel prize 1998) with the capability approach. It is defined by it´s choice of focus upon the significance of individual´s capability of achieving the kind of live they have reason to value. To make sure that there is an individual orientated intervention - as already suggested in the UN Charta - the following capabilities of health and social integration should to be considered: (1) a stabilization of the success in socialization and resilience, (2) a greater cooperation between medical, social and caring powers as elementary instruments of the development of organziation in inpatient and outpatient institutions and (3) a sensivity of generation-bounded experiences of ageing disabled. Mico-sociological there is to regard their specific competences achieved by many years of coping with their personal disabilities on a field of psycho-social capabilities. Important are agencies for the development of functioning and capabilites: (1) by building up a staff with physio-therapists, occupational-therapists and supervisors of staff-planing, (2) by building up healthy organizations and self-help-organizations and 3) by creating strong welfare institutions. Public health and health care will be very important.
International Institute for Healthcare Professionals, USA
Manuel Hernández Triana is a Senior Researcher and full Professor in Biochemistry at the Faculty of Medicine, University of Havana. From 1984-2014, he was the Director of the Department of Biochemistry and Physiology of the Cuban Institute of Nutrition. His research work has been focused to dietary protein quality, energy recommendations and isotopic methods for the measurement of body composition, energy expenditure and Helicobacter pylori infection. He is an expert since 1999 of the International Agency of Atom Energy, International Advisor of the Argentinean National Agency for Science and Technology, President of the Cuban Nutrition Society, Member of the Spanish Nutrition Society and President of the Latin American Nutrition Society from 2009-2012. He is a Member of the Organizing Committees of the ICN and Latin American Nutrition Congresses. He is a Nutrition Professor at the International Institute for Healthcare Professionals, Boca Raton, Florida since 2015.
Statement of the Problem: Cuba is in an advanced stage of the epidemiological transition, where overweight, micronutrient deficiencies and NCDs are highly prevalent. This study evaluated the double burden of stunting, overweight and iron deficiency anemia in children below five years of age and pregnant women.
Methodology & Theoretical Orientation: National surveys of the whole population or from Havana city and data of children and pregnant women from the national food and nutrition surveillance system during 2011 were used for the assessment of the double burden of malnutrition using Cuban national growth charts. Overweight and obesity were 2.5 times higher in stunted than in normal children under five years of age (45% vs. 18%). The double burden in those children was 3.7%, two times higher than the expected prevalence assuming independence in the prevalence of each condition. At six and 24 months of age, the overweight/obesity prevalence was 23% and 31%, and anemia 38% and 15%, respectively. The anemia prevalence within overweight/obese and obese children was quite similar. The proportions with the double burden of anemia and overweight/obesity at six months and two years of age were 8.3% and 3.6%, significantly lower than expected values. At the individual level in pregnant women at the first and third trimester, the prevalence of overweight/obesity was 24% and 22%; 13.9% and 21.7% of them, respectively, were anemic. The double burden of anemia and Ow/Ob was present in 2.6% and 5.1% at the first and third trimester of pregnancy, respectively, values which were also significantly lower than expected.
Conclusion & Significance: Effective actions are required to promote healthy nutrition and linear growth during the first 1000 days of life combined with the prevention of rapid growth after two years of age. This double burden of under nutrition an excess body weight shall be extensively considered in the nutrition programs
Isra University, Pakistan
Time : 11:20-11:55
Nazia Mumtaz has completed her PhD in Rehabilitation Sciences from Isra University, Islamabad, Pakistan. She has been teaching and supervising researches for MS Speech Language Pathology, MS Hearing Sciences. She is also an Associate Editor for the International Journal of Rehabilitation Sciences and Reviewer for the Journal of Riphah College of Rehabilitation Sciences. She is a Consultant SLP at Al-Nafees Medical Hospital, Islamabad. She is also a member of WFNR and Analyst in National newspapers. She has completed the Fellowship in Clinical & Research Neuro Rehabilitation, Department of Rehabilitation Medicine from Seoul National University, Bundang Hospital, Korea. She has also completed her Certification from World Federation for Neuro Rehabilitation Certification in Neurological Rehabilitation, Seoul National University Bundang Hospital, Korea. She has completed her MS/MPhil in Speech Pathology. She is currently working as a HOD of Speech Language Therapy at Al-Nafees Hospital and Member Technical Advisory Group for National Neonatal Hearing Screening Program, Ministry of Health Services & Regulations and Government of Pakistan. She has participated in many international conferences.
Statement of the Problem: Hearing Impairment (HI) in children is globally prevalent and Neonatal Hearing Screening (NHS) programs detect Hearing Loss (HL) in newborns at earliest stage for early intervention leading towards rehabilitation. Such NHS programs have been established in developed countries since decades and implemented in many developing countries except a few like Pakistan. The purpose of this study is to explore priority accorded to NHS, an invisible disability, at health policy level and to identify existing health structure and to determine barriers towards NHS in Pakistan.
Method: An exploratory descriptive qualitative study design conducted with in depth interviews using interview guides from policy makers and hospital administrators in public hospitals in Islamabad. Data recorded was transcribed, thematic analyses drawn manually and verified with help of two separate coders.
Findings: Barriers that emerged were lack of policies and scientific focus during policy formation, legislation and fragile health system at federal and provincial level, lack of advocacy and public awareness, not sensational issue hence not focus of media, lack of technical advice by WHO and international donor agencies, poor health infrastructure, burden on tertiary care, deliveries at homes especially in rural areas with assistance of Trained Birth Attendants (TBA), inadequate fiscal resources, lack of referral and integrated approach at intra departmental levels.
Conclusion: The study concludes that barriers to NHS are lack of financial resources towards the health sector and scarcity of research and reliable data affects the initiation of NHS programs. It is recommended to initiate NHS in Pakistan without any further delay. State should devise policies and provide financial support and resources for NHS. A phased NHS program is need of time which can subsequently be converted into a full-fledged national hearing screening project for entire population.
Hospital Saint Louis Lariboisiere, France
Keynote: Microbiota mitochondrial metabolism
Time : 11:55-12:30
Richard Haddad is French Doctor with 41 years of expertise in MD and Nutrition. He has been in the Faculty of Medicine of Paris from 1969 to 1977. In 1993, he initiated his 1st Holistic Health Centre. In the year of 2008, he started Zen Clinic and Holistic Health Centre in Levallois. In 2014, he published his first books about the role of microbiota. He has also been the Author of The secret host of the gut: Microbiota. In 2018, he started Institute of Microbiota and Mitochondria and New Nutrition
The microbiota is recognized by scientists around the world as a real organ of our body with billions of microbes at the centre of biological and even neurological balance; for example, the action of production of neuromodulators synthesized on site by the digestive mucosa and this flora. The intestine becomes an organ, a platform for regulating our metabolism and our body. It is also named: “the second brain”, and near it, lives this flora that now proudly bears the name of microbiota. Based on the latest scientific findings, Dr. Richard Haddad explains the impact of the microbiota on our health and its impact on diseases such as diabetes, hypertension, obesity, etc. He creates the “Microbiotic Diet”. For more than 40 years, Dr. Richard Haddad has been interested in weight gain and the mechanisms that lead to effective dieting. As a specialist in nutrition, in the management of obesity and diabetes, he leads many conferences about this subject. The notion that emerges from all this work is that the prebiotics fibres play an important and even essential role in the metabolism of our organism with a coordinated action with each cell via the mitochondria, also of bacterial origin. He proposes a new term for this metabolic process: “the supply chain for health”.
Introduction: The rate of obesity and diabetes has been growing steadily for many years, to combat this, Dr. Haddad has spent 40 years of professional practice looking for the ideal diet. The discovery of the role of Microbiota and the action of prebiotics has completely undermined the metabolic and dietetic approach of Nutrition. Approach often difficult to understand even for specialists.
It is certain that the origin of life on earth has been bacterial for 4 billion and 1/2 years. The persistence of billions of bacteria in our organism is for me the normal extension of this collaboration for the creation of life on earth. This advanced commensalism allowed the presence of a bacterial emissary in the cell itself, in the form of Mitochondria. And Mitochondria also have a bacterial origin. Microbiota and Mitochondria work in close collaboration for the survival of our organism. The deficiency of this microbial couple (by pesticides, heavy metals .) is then at the origin of all or part of the diseases of our industrial period. Since a long time, people use fermented products: the probiotics.
a. Probiotic foods have been widely used, for thousands of years, to improve their health by all people depending on their type of diet.
b. Ginger beer gaseous, naturally fermented, probiotic drink appeared in England in the1800s.
c. Kefir This thick and pungent yogurt drink contains a wide variety of probiotic bacteria
d. Kimchi With a spicy flavor (garlic, salt, peppers, vinegar) is very popular in Korea
e. Kombucha fermented sweet black tea since 2000 years in China.
f. Miso Thick soy paste plus a mushroom kojikin, very salty and very spicy.
g. Sauerkraut Fermented shredded cabbage, use cooled fresh form.
h. Yogurt Fermented dairy product with “live and active cultures”
i. Fortunately, the discovery of the prebiotics and their role on the health of the bacteria will allow an improvement and stimulation of all microbiota bacteria and consequently improvement of the health of every people
The prebiotic foods are, now, going to be used more and more, The most used in the United States is inulin but poorly tolerated in high doses, other FOS and GOS are better supported at high therapeutic doses; And it is certain now that they interact with the bacteria of the intestine, the Microbiota, triggering the metabolic reactions that we will see.2 It is certain that the microbiota with prebiotics, but also stimulated by them, leads to a cascade of reactions, with formation of short chain fatty acid, and other metabolites : neurotransmitters that, with mitochondria are part of a metabolic process from the origin. This process provides each cell of our body with the minimum amount of nutrients. In detail, the main metabolites of the microbiota are: short chain fatty acids, urolithins and lactate. In particular, butyrate, which is produced by fermentation of non-digestible fibers by a number of different bacterial lines, and activates AMP Kinase. The microbial diversity enhances productivity, which improves mitochondriogenesis or Mitobioba for Zorov and co (microbiota / mitochondria relationship). The ultimate goal of this process: to give to the cell and to the mitochondria nutrients and energy. Here, I think, but the future will confirm, that energy efficiency with prebiotics is immeasurably higher than that of probiotic.3
The role of the Intestine has been better defined, and in fact its role as a waste receptacle passes second, leaving the role of Microbiota in the foreground with the action of billions of bacteria on our metabolism. But the discovery of soluble prebiotic fibers revolutionizes the approach of Nutrition. In fact, the soluble prebiotic fibers by their stimulating effect on the Microbiota and the liberated AG regulate our entire Metabolism. The European institutions in Brussels confirm this work and attribute two allegations “Health” to prebiotic fibers: one on food drives, and one on decrease in caries. In the Dietetic Diet “Microbiotic Diet” (www.regimeefficace.net) Dr. Haddad uses prebiotic fibers in Obesity and Diabetes An anomaly in this system, in this supply chain, leads to disease, cancer and death.