Massimo Collino
University of Turin, Italy
Title: Salivary AGEs as novel biomarkers of risk factors in diet-related diseases: preliminary results of the EU SALIVAGES Network
Biography
Biography: Massimo Collino
Abstract
Abstract:
Advanced Glycation End Products (AGEs) are reactive compounds deriving from glycoxidation reactions between the amino groups of proteins and reducing carbohydrates. Recent findings convincingly demonstrate that Advanced Glycation End Products (AGEs) are modifiable by diet and reflect changes in healthy state. The multidisciplinary project SALIVAGES, granted by the Eupean ERA-HDHL programme, focuses on the identification and validation of non-invasive strategies for monitoring AGEs in the saliva as early and easily accessible biomarkers that are modulated by diet and that potentially indicate a change in health status and/or the risk of developing diet-related diseases. The scientific network involves five different European countries: ITALY (University of Turin), SPAIN (University of Oviedo), IRLAND (National University of Ireland Galway), ROMANIA (University of Cluj-Napoca), GERMANY ((Technische Universität Dresden). Preliminary data based on the integration of preclinical biological and molecular studies, analytical and food chemistry, information technologies, and glycomic analyses will be illustrated and discussed.
Overall, the expected results will contribute to create a paradigm shift and reveal new scientific, technological and scholarly horizons in the identification of non-invasive strategies for monitoring biomarkers that are modifiable by diet and reflect either a healthy state, or its transition towards diet-related disease.