Day 1 :
Keynote Forum
Massimo Collino
University of Turin, Italy
Keynote: Salivary AGEs as novel biomarkers of risk factors in diet-related diseases: Preliminary results of the EU SALIVAGES Network
Time : 09:20-09:55
Biography:
Massimo Collino is Professor of Pharmacology and Toxicology, Dept. Drug Science and Technology, University of Turin (Italy). He is author of 86 full papers published in international journals with Impact Factor; Citations: 1886 total citations h-index: 25. He is the European Coordinator of the European Project “Innovative Technological Approaches for validation of Salivary AGEs as novel biomarkers in evaluation of risk factors for diet-related diseases”
Abstract:
Advanced Glycation End Products (AGEs) are reactive compounds deriving from glycoxidation reactions between the amino groups of proteins and reducing carbohydrates. Recent findings convincingly demonstrate that Advanced Glycation End Products (AGEs) are modifiable by diet and reflect changes in healthy state. The multidisciplinary project SALIVAGES, granted by the Eupean ERA-HDHL programme, focuses on the identification and validation of non-invasive strategies for monitoring AGEs in the saliva as early and easily accessible biomarkers that are modulated by diet and that potentially indicate a change in health status and/or the risk of developing diet-related diseases. The scientific network involves five different European countries: ITALY (University of Turin), SPAIN (University of Oviedo), IRLAND (National University of Ireland Galway), ROMANIA (University of Cluj-Napoca), GERMANY ((Technische Universität Dresden). Preliminary data based on the integration of preclinical biological and molecular studies, analytical and food chemistry, information technologies, and glycomic analyses will be illustrated and discussed.
Overall, the expected results will contribute to create a paradigm shift and reveal new scientific, technological and scholarly horizons in the identification of non-invasive strategies for monitoring biomarkers that are modifiable by diet and reflect either a healthy state, or its transition towards diet-related disease.
Keynote Forum
Bernhard Mann
University of Koblence-Landau, Germany
Keynote: The supply of the disabled becoming elderly by the capability approach by Amartya Sen
Time : 09:55-10:30
Biography:
Bernhard Mann has completed his MA (Social Science) in Erlangen-Nuernberg, his PhD (Social Gerontology) in Kassel and his MPH (Public Health) at the Medical University of Hannover. He was Adjunct Professor and Full Professor of Health and Social Management at Universities and Universities of Applied Sciences in Germany. His scientific interest is the psycho-social structure of the quality of life. He got international experiences in India, Japan, Mexico, Israel, Great Britain, France etc..especially in the context with basic education by Mahatma Gandhi.
Abstract:
The demographic chance of the human population is globally. The number of elderly is growing: Year 1988 – 416.000.000 are 60+. Year 2025 – 806.000.000 (72 % in developing countries). As well as the life expectation of adult handicaps is increasing too. In FRG, 60+ seriously handicapped with 100 % by nearly 800 000. Familiy care for the handicaps could not be guaranteed. Parents are stressed, getting ill or come to the end of life. A system of care for the adult handicaps will be very important. They have to cope with cumulative problems such as physical, psychological and social straints. This phenomenon is known as multiple jeopardy. The question will be how to create a valuable life for an indivdual in order to improve the capabilities. Systems for care of the elderly cannot be transfered easily among countries, as the WHO approach is told. A scientific way about prevention and health promotion gives Armatya Sen (novel prize 1998) with the capability approach. It is defined by it´s choice of focus upon the significance of individual´s capability of achieving the kind of live they have reason to value. To make sure that there is an individual orientated intervention - as already suggested in the UN Charta - the following capabilities of health and social integration should to be considered: (1) a stabilization of the success in socialization and resilience, (2) a greater cooperation between medical, social and caring powers as elementary instruments of the development of organziation in inpatient and outpatient institutions and (3) a sensivity of generation-bounded experiences of ageing disabled. Mico-sociological there is to regard their specific competences achieved by many years of coping with their personal disabilities on a field of psycho-social capabilities. Important are agencies for the development of functioning and capabilites: (1) by building up a staff with physio-therapists, occupational-therapists and supervisors of staff-planing, (2) by building up healthy organizations and self-help-organizations and 3) by creating strong welfare institutions. Public health and health care will be very important.
Keynote Forum
Manuel Hernandez Triana
International Institute for Healthcare Professionals, USA
Keynote: Double burden of malnutrition in Cuba
Biography:
Manuel Hernández Triana is a Senior Researcher and full Professor in Biochemistry at the Faculty of Medicine, University of Havana. From 1984-2014, he was the Director of the Department of Biochemistry and Physiology of the Cuban Institute of Nutrition. His research work has been focused to dietary protein quality, energy recommendations and isotopic methods for the measurement of body composition, energy expenditure and Helicobacter pylori infection. He is an expert since 1999 of the International Agency of Atom Energy, International Advisor of the Argentinean National Agency for Science and Technology, President of the Cuban Nutrition Society, Member of the Spanish Nutrition Society and President of the Latin American Nutrition Society from 2009-2012. He is a Member of the Organizing Committees of the ICN and Latin American Nutrition Congresses. He is a Nutrition Professor at the International Institute for Healthcare Professionals, Boca Raton, Florida since 2015.
Abstract:
Statement of the Problem: Cuba is in an advanced stage of the epidemiological transition, where overweight, micronutrient deficiencies and NCDs are highly prevalent. This study evaluated the double burden of stunting, overweight and iron deficiency anemia in children below five years of age and pregnant women.
Methodology & Theoretical Orientation: National surveys of the whole population or from Havana city and data of children and pregnant women from the national food and nutrition surveillance system during 2011 were used for the assessment of the double burden of malnutrition using Cuban national growth charts. Overweight and obesity were 2.5 times higher in stunted than in normal children under five years of age (45% vs. 18%). The double burden in those children was 3.7%, two times higher than the expected prevalence assuming independence in the prevalence of each condition. At six and 24 months of age, the overweight/obesity prevalence was 23% and 31%, and anemia 38% and 15%, respectively. The anemia prevalence within overweight/obese and obese children was quite similar. The proportions with the double burden of anemia and overweight/obesity at six months and two years of age were 8.3% and 3.6%, significantly lower than expected values. At the individual level in pregnant women at the first and third trimester, the prevalence of overweight/obesity was 24% and 22%; 13.9% and 21.7% of them, respectively, were anemic. The double burden of anemia and Ow/Ob was present in 2.6% and 5.1% at the first and third trimester of pregnancy, respectively, values which were also significantly lower than expected.
Conclusion & Significance: Effective actions are required to promote healthy nutrition and linear growth during the first 1000 days of life combined with the prevention of rapid growth after two years of age. This double burden of under nutrition an excess body weight shall be extensively considered in the nutrition programs
Keynote Forum
Nazia Mumtaz
Isra University, Pakistan
Keynote: Barriers to neonatal hearing screening in Pakistan
Time : 11:20-11:55
Biography:
Nazia Mumtaz has completed her PhD in Rehabilitation Sciences from Isra University, Islamabad, Pakistan. She has been teaching and supervising researches for MS Speech Language Pathology, MS Hearing Sciences. She is also an Associate Editor for the International Journal of Rehabilitation Sciences and Reviewer for the Journal of Riphah College of Rehabilitation Sciences. She is a Consultant SLP at Al-Nafees Medical Hospital, Islamabad. She is also a member of WFNR and Analyst in National newspapers. She has completed the Fellowship in Clinical & Research Neuro Rehabilitation, Department of Rehabilitation Medicine from Seoul National University, Bundang Hospital, Korea. She has also completed her Certification from World Federation for Neuro Rehabilitation Certification in Neurological Rehabilitation, Seoul National University Bundang Hospital, Korea. She has completed her MS/MPhil in Speech Pathology. She is currently working as a HOD of Speech Language Therapy at Al-Nafees Hospital and Member Technical Advisory Group for National Neonatal Hearing Screening Program, Ministry of Health Services & Regulations and Government of Pakistan. She has participated in many international conferences.
Abstract:
Statement of the Problem: Hearing Impairment (HI) in children is globally prevalent and Neonatal Hearing Screening (NHS) programs detect Hearing Loss (HL) in newborns at earliest stage for early intervention leading towards rehabilitation. Such NHS programs have been established in developed countries since decades and implemented in many developing countries except a few like Pakistan. The purpose of this study is to explore priority accorded to NHS, an invisible disability, at health policy level and to identify existing health structure and to determine barriers towards NHS in Pakistan.
Method: An exploratory descriptive qualitative study design conducted with in depth interviews using interview guides from policy makers and hospital administrators in public hospitals in Islamabad. Data recorded was transcribed, thematic analyses drawn manually and verified with help of two separate coders.
Findings: Barriers that emerged were lack of policies and scientific focus during policy formation, legislation and fragile health system at federal and provincial level, lack of advocacy and public awareness, not sensational issue hence not focus of media, lack of technical advice by WHO and international donor agencies, poor health infrastructure, burden on tertiary care, deliveries at homes especially in rural areas with assistance of Trained Birth Attendants (TBA), inadequate fiscal resources, lack of referral and integrated approach at intra departmental levels.
Conclusion: The study concludes that barriers to NHS are lack of financial resources towards the health sector and scarcity of research and reliable data affects the initiation of NHS programs. It is recommended to initiate NHS in Pakistan without any further delay. State should devise policies and provide financial support and resources for NHS. A phased NHS program is need of time which can subsequently be converted into a full-fledged national hearing screening project for entire population.
Keynote Forum
Richard Haddad
Hospital Saint Louis Lariboisiere, France
Keynote: Microbiota mitochondrial metabolism
Time : 11:55-12:30
Biography:
Richard Haddad is French Doctor with 41 years of expertise in MD and Nutrition. He has been in the Faculty of Medicine of Paris from 1969 to 1977. In 1993, he initiated his 1st Holistic Health Centre. In the year of 2008, he started Zen Clinic and Holistic Health Centre in Levallois. In 2014, he published his first books about the role of microbiota. He has also been the Author of The secret host of the gut: Microbiota. In 2018, he started Institute of Microbiota and Mitochondria and New Nutrition
Abstract:
The microbiota is recognized by scientists around the world as a real organ of our body with billions of microbes at the centre of biological and even neurological balance; for example, the action of production of neuromodulators synthesized on site by the digestive mucosa and this flora. The intestine becomes an organ, a platform for regulating our metabolism and our body. It is also named: “the second brain”, and near it, lives this flora that now proudly bears the name of microbiota. Based on the latest scientific findings, Dr. Richard Haddad explains the impact of the microbiota on our health and its impact on diseases such as diabetes, hypertension, obesity, etc. He creates the “Microbiotic Diet”. For more than 40 years, Dr. Richard Haddad has been interested in weight gain and the mechanisms that lead to effective dieting. As a specialist in nutrition, in the management of obesity and diabetes, he leads many conferences about this subject. The notion that emerges from all this work is that the prebiotics fibres play an important and even essential role in the metabolism of our organism with a coordinated action with each cell via the mitochondria, also of bacterial origin. He proposes a new term for this metabolic process: “the supply chain for health”.
Introduction: The rate of obesity and diabetes has been growing steadily for many years, to combat this, Dr. Haddad has spent 40 years of professional practice looking for the ideal diet. The discovery of the role of Microbiota and the action of prebiotics has completely undermined the metabolic and dietetic approach of Nutrition. Approach often difficult to understand even for specialists.
It is certain that the origin of life on earth has been bacterial for 4 billion and 1/2 years. The persistence of billions of bacteria in our organism is for me the normal extension of this collaboration for the creation of life on earth. This advanced commensalism allowed the presence of a bacterial emissary in the cell itself, in the form of Mitochondria. And Mitochondria also have a bacterial origin. Microbiota and Mitochondria work in close collaboration for the survival of our organism. The deficiency of this microbial couple (by pesticides, heavy metals .) is then at the origin of all or part of the diseases of our industrial period. Since a long time, people use fermented products: the probiotics.
The probiotics
a. Probiotic foods have been widely used, for thousands of years, to improve their health by all people depending on their type of diet.
b. Ginger beer gaseous, naturally fermented, probiotic drink appeared in England in the1800s.
c. Kefir This thick and pungent yogurt drink contains a wide variety of probiotic bacteria
d. Kimchi With a spicy flavor (garlic, salt, peppers, vinegar) is very popular in Korea
e. Kombucha fermented sweet black tea since 2000 years in China.
f. Miso Thick soy paste plus a mushroom kojikin, very salty and very spicy.
g. Sauerkraut Fermented shredded cabbage, use cooled fresh form.
h. Yogurt Fermented dairy product with “live and active cultures”
i. Fortunately, the discovery of the prebiotics and their role on the health of the bacteria will allow an improvement and stimulation of all microbiota bacteria and consequently improvement of the health of every people
The prebiotics
The prebiotic foods are, now, going to be used more and more, The most used in the United States is inulin but poorly tolerated in high doses, other FOS and GOS are better supported at high therapeutic doses; And it is certain now that they interact with the bacteria of the intestine, the Microbiota, triggering the metabolic reactions that we will see.2 It is certain that the microbiota with prebiotics, but also stimulated by them, leads to a cascade of reactions, with formation of short chain fatty acid, and other metabolites : neurotransmitters that, with mitochondria are part of a metabolic process from the origin. This process provides each cell of our body with the minimum amount of nutrients. In detail, the main metabolites of the microbiota are: short chain fatty acids, urolithins and lactate. In particular, butyrate, which is produced by fermentation of non-digestible fibers by a number of different bacterial lines, and activates AMP Kinase. The microbial diversity enhances productivity, which improves mitochondriogenesis or Mitobioba for Zorov and co (microbiota / mitochondria relationship). The ultimate goal of this process: to give to the cell and to the mitochondria nutrients and energy. Here, I think, but the future will confirm, that energy efficiency with prebiotics is immeasurably higher than that of probiotic.3
Conclusion
The role of the Intestine has been better defined, and in fact its role as a waste receptacle passes second, leaving the role of Microbiota in the foreground with the action of billions of bacteria on our metabolism. But the discovery of soluble prebiotic fibers revolutionizes the approach of Nutrition. In fact, the soluble prebiotic fibers by their stimulating effect on the Microbiota and the liberated AG regulate our entire Metabolism. The European institutions in Brussels confirm this work and attribute two allegations “Health” to prebiotic fibers: one on food drives, and one on decrease in caries. In the Dietetic Diet “Microbiotic Diet” (www.regimeefficace.net) Dr. Haddad uses prebiotic fibers in Obesity and Diabetes An anomaly in this system, in this supply chain, leads to disease, cancer and death.
Keynote Forum
Massimo Collino
University of Turin, Italy
Keynote: Salivary AGEs as novel biomarkers of risk factors in diet-related diseases: preliminary results of the EU SALIVAGES Network
Time : 09:00-09:45
Biography:
Massimo Collino is Professor of Pharmacology and Toxicology, Dept. Drug Science and Technology, University of Turin (Italy).He is author of 86 full papers published in international journals with Impact Factor; Citations: 1886 total citations h-index: 25. He is the European Coordinator of the European Project “Innovative Technological Approaches for validation of Salivary AGEs as novel biomarkers in evaluation of risk factors for diet-related diseases”
Abstract:
Abstract:
Advanced Glycation End Products (AGEs) are reactive compounds deriving from glycoxidation reactions between the amino groups of proteins and reducing carbohydrates. Recent findings convincingly demonstrate that Advanced Glycation End Products (AGEs) are modifiable by diet and reflect changes in healthy state. The multidisciplinary project SALIVAGES, granted by the Eupean ERA-HDHL programme, focuses on the identification and validation of non-invasive strategies for monitoring AGEs in the saliva as early and easily accessible biomarkers that are modulated by diet and that potentially indicate a change in health status and/or the risk of developing diet-related diseases. The scientific network involves five different European countries: ITALY (University of Turin), SPAIN (University of Oviedo), IRLAND (National University of Ireland Galway), ROMANIA (University of Cluj-Napoca), GERMANY ((Technische Universität Dresden). Preliminary data based on the integration of preclinical biological and molecular studies, analytical and food chemistry, information technologies, and glycomic analyses will be illustrated and discussed.
Overall, the expected results will contribute to create a paradigm shift and reveal new scientific, technological and scholarly horizons in the identification of non-invasive strategies for monitoring biomarkers that are modifiable by diet and reflect either a healthy state, or its transition towards diet-related disease.
- Nutrition & Health | Food and Nutrition | Clinical Nutrition | Malnutrition or Nutritional Deficiency |Nutrition and Food Safety | Nutrition in Cancer Treatment
Chair
Richard Haddad
Hospital Saint Louis Lariboisiere, France
Co-Chair
Nazia Mumtaz
Isra University, Pakistan
Session Introduction
Bronwen de Klerk
Bronwen de Klerk, UK
Title: Yoga and mindful eating: Balancing nutritional needs intuitively
Biography:
Bronwen de Klerk is a Yoga and Mindful Eating Teacher. She battled with eating disorders in her earlier years and found peace with food and eating through spiritual practice. She has since studied and qualified in yoga, shiatsu, mindfulness-based eating awareness training, clinical nutrition, Pilates and Exercise Science. She is a Member of the International Yoga Alliance (RYT), Shiatsu Society UK (MRSS) and REPs (Level 3). She teaches yoga and mindful eating privately and in groups, online and live. She runs yoga teacher training for the Meridian Yoga School. She gives talks and runs retreats internationally through her business Surf Yoga Happiness LTD.
Abstract:
Whilst advancement in nutrition sciences has helped many people to overcome illness and disease, we have more people battling with obesity than ever before on this planet. How can it be that we have more knowledge than ever about food and what it does for us, but more problems with overeating and obesity? We can blame it on sugar, refined carbohydrates, trans fats, fried foods and many other unhealthy food options we now have available, but what it really comes down to is that we have lost touch with ourselves and our bodies. We have forgotten how to tune in and truly listen to what our bodies need. What doesn’t help is that we’re living in a world of distraction. We all know exactly what our bodies need, nutritionally and energetically. The only problem is that we spend most of our lives distracted so that we don’t actually tunein and listen to this guiding voice. From a young age we are becoming distracted by television, social media, gaming and devices. Marketing messages are constantly telling us that we are not good enough, but if we ‘buy this’, ‘eat this’ or ‘do that’ we will be good enough. We are always striving to be somewhere or something we are not; we are no longer present. This is one of core teachings of yoga and mindfulness–awareness of the present moment. Through the various practices of yoga and mindfulness, we will learn how to become present in our bodies. We will also learn how to accept where we are and who we are. Through acceptance and presence, we can become more aware of what our bodies need – when we are hungry, when we are full and what we need to nourish ourselves in terms of food and movement.
Biography:
Collino M is a Professor of Pharmacology and Toxicology in the Department of Drug Science and Technology at University of Turin (Italy). He is author of 86 full papers published in international journals with high impact factor; total citations: 1886; h-index: 25. He is the European Coordinator of the European Project “Innovative technological approaches for validation of salivary AGEs as novel biomarkers in evaluation of risk factors for diet-related diseases”.
Abstract:
Fructose produces 10 times more advanced glycation end products (AGEs) than glucose. We had recently demonstrated that the high chemical reactivity of fructose contributes to the massive formation of intracellular AGEs, thus evoking marked cellular alterations and organ dysfunction. Here, we investigated whether not only the type (e.g. fructose vs. glucose), but also the form (liquid vs. solid) of sugars may affect the development of metabolic impairments. Male C57Bl/6j mice were fed a standard diet (SD), a standard diet plus 60% fructose syrup (L-Fr), or a 60% fructose solid diet plus water (S-Fr), for 12 weeks. Liver lipogenesis, fibrosis, and inflammation, as well as intestinal absorption, accumulation of AGEs, and integrity were assessed by WB, immunofluorescence and histology. Gut microbiota population was characterized by metagenomic sequencing. L-Fr intake induced higher levels of hepatosteatosis associated to a greater expression/activation of the lipogenic SCAP/SREBP signaling pathway and fibrogenic markers in the liver than the S-Fr administration. In contrast, S-Fr evoked in the ileum intestinal mucosa a stronger local AGEs accumulation, RAGE expression, and gut barrier injury, leading to higher concentration of LPS in the portal plasma. The S-Fr related impairment of gut integrity was associated to a stronger activation of the LPS-dependent pro-inflammatory pathway NLRP3 inflammasomein the liver of S-Fr mice than L-Fr mice. Interestingly, the local accumulation of fructose in the intestine led to alterations of the gut microbiota depending on the fructose formulation. Overall, these results convincingly showed that the consumption of different fructose formulations, liquid or solid, may evoke different impact on gut integrity, thus differently affecting liver homeostasis. Our data suggest that, the solid fructose formulation is more slowly absorbed by enterocytes than liquid fructose, thus producing AGEs, leading to systemic inflammation.
Rami Saadeh
Jordan University of Science and Technology, Jordan
Title: To determine the association of four upper air indicators and seven air pollutants with Attention Deficit Hyperactivity Disorder (ADHD) in elementary school children in Pennsylvania over a three-years period
Time : 12:30-12:55
Biography:
Rami Saadeh is an Assistant Professor in Jordan University of Science and Technology in Jordan. He earned his Bachelor of Dental Surgery (BDS) from Jordan, MSPH from Tulane University in Louisiana, US and PhD in Environmental Health and Epidemiology from Indiana University, US, and has a specialty in Dental Public Health from the University of Texas Health at San Antonio, Texas, US. He worked as a Dentist in small villages and Palestinians’ refugee camps in Jordan, taught Public Health courses for years in Jordan, Saudi Arabia, and the US, and worked as the State Oral Health Epidemiologist in West Virginia. His research focuses on children and disadvantaged populations. His passion is to support equity in healthcare, and he is eager to see low socioeconomic populations gain equitable access to health care.
Abstract:
Objective: The objective of the study is to determine the association of four upper air indicators and seven air pollutants with Attention Deficit Hyperactivity Disorder (ADHD) in elementary school children in Pennsylvania over a three-year period.
Method: An ecological study design that included records of 168,825 children from elementary schools distributed in 49 Pennsylvania counties was used. The number of children with ADHD exacerbations was extracted from online software specifically designed to record health conditions in schools. Daily measurements of air pollutants and upper air indicators were gained from the US Environmental Protection Agency and from the University of Wyoming, respectively. Generalized estimating equation models with Poisson regression as well as a one-way ANOVA were used in the analysis.
Result: The number of ADHD exacerbations significantly increased over the 3-year period [163.9 (±70.1) in 2008, 317.2 (±84.4) in 2009, and 427 (±101.4) in 2010]. Although exacerbations of ADHD fluctuated among months of each year, summer had the lowest number of exacerbations [233.05 (±111.3)], while fall had the highest [367.81(±96.8)]. Further, the difference in the number of ADHD exacerbations among the three years and among the four seasons for all years were statistically significant (P<0.001). Five air pollutants SO2, CO, NO2, PM2.5, PM10 and one upper air indicator were significant in the model and no interactions among predictors were significant.
Conclusion: Upper air indicators and pollutants were useful tools to predict ADHD in school children, which help parents and school administration to take appropriate precautionary actions.
Mauricio Lisboa Nobre
Federal University of Rio Grande do Norte, Brazil
Title: A new strategy to halt leprosy transmission: A Brazilian experience
Time : 12:55-13:20
Biography:
Mauricio Lisboa Nobre is a Physician specialized in Dermatology and Leprology. He has completed his PhD in Tropical Medicine by the Oswaldo Cruz Foundation (Rio de Janeiro). His main activities include the training of doctors and nurses from the Brazilian Family Health Program on Leprosy Management. He also supports field researches conducted by the Tropical Medicine Institute of Rio Grande do Norte Federal University, especially on leprosy epidemiology and contact tracing. He acts as an Adviser for the Brazilian Ministry of Health, Pan-American Health Organization (PAHO) and ILEP agencies
Abstract:
Leprosy is an important public health problem in Brazil, where 25,218 new cases were reported in 2016. Patients with weak resistance against Mycobacterium leprae develop Multibacillary (MB) types of disease and spread the infection. We analyzed 541,090 cases notified in Brazil from 2003-2013, observing that New Cases Detection Rates (NCDR) for MB leprosy increased with age, especially for men, reaching 44.8 new cases/100,000 male population in 65-69-year-old group, while overall NCDR was 2-fold lower. Males had twice the odds of MB leprosy than females (OR=2.36, CI95%=2.33-2.38); the same was observed for patients older than 59 years (OR=1.99, CI 95%=1.96-2.02) compared to youngers. These findings were reported only in areas where leprosy was declining and exposure to infection was reduced, promoting a later onset of disease. However, we observed this pattern for MB leprosy in all Brazilian states, either with the highest NCDR (104.5 new cases/100,000) or the lowest NCDR (1.7 cases/100,000). Additionally, we selected a highly endemic urban area to search for MB leprosy cases among elderly population. As a result, 80% of all residents aged 60 or more years old (531 people) were checked for ML specific antibodies and three new cases of MB leprosy were detected among 188 men (NCDR=1.6%). No new case was detected among 316 women tested. These results suggest that age-specific campaigns should be addressed to increase earlier detection and treatment of MB cases among elderly men in endemic areas, as an important tool to effectively halt leprosy transmission in Brazil
Juliana Paludo Vallandro
Federal University of Rio Grande do Sul, Brazil
Title: Adductor muscle thickness of the thumb: A new and reliable parameter for nutritional assessment of pediatric inpatients
Biography:
Juliana Paludo Vallandro has completed her Doctorate degree from the Federal University of Rio Grande do Sul, which is one of the best three universities in Brazil, according to the Ministry of Education. She is currently pursuing her Post-doctorate degree in Child and Adolescent Health from the same university. She is a Level I-Assistant Professor in the Undergraduate Nutrition course at Ritter dos Reis University, which belongs to the Laureate teaching network, and also teaches several Lato Sensu graduate courses. She has published 14 scientific papers in national and international journals.
Abstract:
The adductor pollicis muscle thickness (APMT) is a promising method for evaluation of muscle loss and, consequently, malnutrition in adult and elderly patients. Within this context, we sought to evaluate the association of APMT with anthropometric variables, body mass index (BMI), pediatric subjective global assessment (SGA) of nutrition, nutritional screening, and clinical outcomes in hospitalized pediatric patients. This is a cross-sectional study of hospitalized patients between the ages of four and 8.9 years, with convenience sampling, performed at a pediatric hospital in Rio Grande do Sul. Patients admitted to the intensive care unit, those who could not orally take food and those with cerebral palsy or Down syndrome were excluded. General and socioeconomic information was collected and SGA Ped and STRONGkids were administered at hospital admission. The clinical data were collected in the electronic medical record. The sample consisted of 447 patients. Most of them, (55.9%) were male; the mean age was 6.2±1.4 years. Low APMT was significantly associated with underweight, short stature, low body fat percentage, and poor muscle reserve (p<0.001). There were also significant associations of moderate and severe malnutrition (assessed by the SGA Ped) and high nutritional risk (assessed by the STRONGkids instrument) with reduced APMT (p<0.001). A longer hospital stay was observed in patients with reduced APMT (p=0.001). A receiver operating characteristic (ROC) curve, plotted considering the SGA Ped as the gold standard, suggested APMT cutoff points of 10.2 mm for boys and 9.5 mm for girls. Stratification by age yielded APMT cutoff points of 9.8 mm for boys younger than six years and 10.2 mm for those older than six years, and 9.2 mm and 9.8 mm for girls younger and older than six years, respectively. The APMT is an efficient parameter for the detection of malnutrition in hospitalized pediatric patients.
Vanesa Cepas
Universidad de Oviedo, Spain
Title: Antioxidants prevent keratinocyte death by dietary Advanced Glycation Endproducts
Biography:
Vanesa Cepas has studied a Bachelor’s Degree in Biology at University of Oviedo, where she also studied a Master’s Degree in Biomedicine and Molecular Oncology. Nowadays she is a PhD student in University Institute for Oncology of Principality of Asturias (IUOPA) and is a researcher in JPI-HDHL project “SALIVAGES”. Her research interests are redox biology, stem cells and cell differentiation.
Abstract:
Introduction: In the last 40 years, diets composition has changed in developed countries and are nowadays characterized by an elevated glucose and fructose intake, mainly due to the increased consumption of processed sweetened foods and drinks. Fructose intake increases circulatory Advanced Glycation Endproducts (AGEs) and their tissue accumulation. These compounds are formed during the Maillard reaction initiated by a nucleophilic addition between the carbonyl group of a saccharide and the free amino group of a protein, aminophospholipid or nucleic acid. Protein glycation takes place both in vivo, in tissues and fluids under physiological conditions, and ex vivo, during food preparation such as baking, cooking or frying as well as during storage. AGEs are involved in the pathogenesis of diet-related diseases such as diabetes, insulin resistance, cardiovascular diseases, kidney injury or age-related and neurodegenerative diseases. Methods: We tested the toxicity of 2 independent compounds: 3-deoxygalactosone (3-DGal) and 3,4-dideoxyglucosone-3-ene (3,4-DGE) synthesized by SALIVAGES group. We incubated human keratinocytes (HaCaT) with several concentrations of each compound and/or well-known antioxidants for 48 hours. Furthermore, we treated HaCaT cells with ferrostatin-1, 3-methyladenine and necrostatin-1 to assay cell death performing a trypan-blue staining. Results: 3-DGal reduces cell viability to 80% and cell concentration to 22%. N-acetylcysteine reverts 3-DGal effect by increasing cell viability and concentration to 100% and 68% respectively. Interestingly, we found that neither ferrostatin-1, nor 3-methyladenine, nor necrostatin-1 prevented cell death, therefore these AGEs induce a form of cell death such as necrosis or apoptosis. Conclusions: N-acetylcysteine reverts the effect of 3-DGal. These AGEs could induce cell death through apoptosis or necrosis.
Soyoka Yoshimi
Kyoto University, Japan
Title: Effects of physical activity on premenstrual syndrome in university students
Time : 16:55-17:20
Biography:
Soyoka Yoshimi has completed her graduation ranking first in her class in the Department of Physical Therapy and Human Health Sciences from the Kyoto University. She has experience as a Physical Therapist not only in Japan but also in a foreign country. She has been to study abroad during her Master’s course of Human Health Sciences almost half of year, and has continued research with abroad graduate school by her own.
Abstract:
Introduction: Main treatment of premenstrual syndrome (PMS) which is more severe among young women is pharmacological therapy with high risk of adverse effects. In spite of demand of non-pharmacological therapy of PMS, the number of studies demonstrating the effectiveness of non-pharmacological therapy for PMS in young women is quite a few.
Aim: This study aimed to determine the adequate volume of physical activity on PMS in university students.
Materials & Methods: The study subjects included 435 female university students. Spearman rank correlation analysis was performed to analyze the exercise intensity of physical activity on PMS symptoms. Each statistical significance level was less than 5%. The mean age of subjects was 20.5±1.2 years. Spearman rank correlation analysis found a negative correlation (p=0.037, r=-0.161) between PMS symptoms and moderate physical activity, but a positive correlation (p=0.038, r=0.159) between PMS symptoms and inactivity.
Findings: These findings could help the young women preventing from or decreasing PMS symptoms at lower risk of adverse effects.
Results: Our results revealed that PMS symptoms had a negative relationship with moderate physical activity and a positive relationship with inactivity in university students.
Helen Adamu
Center for Clinical Care and Research, Nigeria
Title: Implementing antimicrobial consumption surveillance across 14 states in Nigeria
Biography:
Helen Adamu is an Epidemiologist and is the focal person of Antimicrobial Consumption Surveillance representing her organization with the Nigerian Center for Disease Control. Her work created new interest in antimicrobial use surveillance for improved surveillance system. She is an avid Researcher with seven papers published in reputable journals.
Abstract:
Introduction: Several studies show that 80% of antibiotics are consumed in communities than in health facilities. The Nigeria Center for Disease Control (NCDC), University of Maryland (UMB) and Center for Clinical Care and Clinical Research (CCCRN) introduced national antimicrobial consumption surveillance (AMCS) system to provide information on community consumption of antibiotics. This abstract looks at the implementation phase of a novel mobile reporting system for antibiotic use adopted as a strategy for monitoring antibiotic consumption in the community.
Methodology: Fifteen (15) community pharmacists (CPs) were identified across four pilot states in Nigeria. This was later scaled up to 71 CPs across 14 States. Capacity building was held for the CPs on AMCS and use of the tool to collate sales record. This training was carried out in collaboration with the respective state epidemiology units who provide supervisory oversight to the CPs. Monitoring of reports (timeliness and antibiotic use) and quality indicators adapted from the European surveillance of antimicrobial consumption (ESAC) was conducted weekly.
Results: In the first 12 weeks post deployment in the pilot states, average weekly timeliness of report recorded was 40% from 15 CPs. Highest reporting was 58% in week 38 and lowest was 20% in week 42. Amoxicillin (J01GB06) was the most sold antibiotic (32.6%) of overall antibiotic sales in four states.
Conclusion: Implementation of AMCS tool for reporting antibiotic sale was successful. The need to expand the tool to other health settings should be considered to provide insight to antibiotic misuse and abuse and help seek appropriate interventions.
Chair
Bernhard Mann
University of Koblence-Landau, Germany
Session Introduction
Massimo Collino, Andrea Mancini, Martine Morzel
Massimo Collino, University of Turin, Italy, Andrea Mancini, Edmund Mach Foundation - Agricultural Institute San Michele All'Adige, Italy, Martine Morzel, Centre des Sciences du Gout et de l'Alimentation, France
Title: Biomarkers in nutrition and health
Time : 10:00-13:00
Biography:
Abstract:
Traditionally, dietary recommendations have been set at the average population level. However, current research is increasingly showing that the risks, benefits and nutritional requirements strongly vary between different population groups and even individuals, depending on their genetic or other characteristics. For example, European citizens generally consume too high levels of salt, sugar and saturated fat. However, there are significant individual differences in tolerance levels of these food constituents among consumers. More research is needed to better define these individual differences in health responses to diets by validated, nutrition and health-related biomarkers. There is a need for biomarkers determining the intake of specific nutrients or food components (for example by using food metabolomics) and to complement the more traditional dietary assessment methodologies. Further, biomarkers that reflect the nutrition-related health status at both individual and group levels are crucial to demonstrate the health effects of certain foods. The workshop will describe few recent projects granted by European ERA HDHL Cofunded Call Biomarkers in Nutrition and Health, within the Joint Programming Initiative “A Healthy Diet for a Healthy Life” (http://www.healthydietforhealthylife.eu/, JPI HDHL), which has been established to coordinate research in the areas of food, diet, physical activity and health in order to achieve tangible societal and health impact and to strengthen European leadership and competitiveness in this field.
Seong Wu Yang
Bundang Jesaeng Hospital, Republic of Korea
Title: Sleep-disordered breathing and Alzheimer’s disease: A nationwide cohort study
Biography:
Seong Wu Yang is MD, currently training internal medicine residency in Bundang Jesaeng Hospital, South Korea. He pursued his graduation from Yonsei University, College of Medicine. He completed his Bachelor's degree of Business Administration from Hankuk University of Foreign Studies.
Abstract:
One person is diagnosed with dementia in Korea every 12 minutes. According to the Ministry of Health and Welfare, the number of patients with dementia in 2017 was estimated to be about 700,000 and is expected to increase rapidly to 1 million by 2024. According to the OECD report, Alzheimer’s disease (AD) is the most common cause of dementia, accounting for approximately 60–80% of cases of dementia. AD is more common in aging populations. There has been a growing interest in AD and its modifiable risk factors, such as cardiovascular disease (CVD), hypertension, Type 2 diabetes mellitus (DM), depression, obesity, smoking, low physical activity, and drinking. Reducing these modifiable risk factors can prevent AD. Recently, an association between sleep-disordered breathing (SDB) and AD has been suggested. According to a previous study, the prevalence of SDB is estimated to be 27% and 16% in middle-aged Korean men and women, respectively. Recent studies have shown a direct association between SDB and cognitive impairment. However, the association between SDB and AD remains controversial, and only few longitudinal studies have been performed in an Asian population. Therefore, the present study was conducted to investigate whether SDB is associated with AD onset, using representative nationwide cohort data with a 14-year follow-up. The present study used the health check-up cohort data from the National Health Insurance Service (NHIS) claims between 2002 and 2015. The study population comprised about 10% of the 5.15 million subjects aged 40–79 years who participated in the national medical check-up between 2002 and 2003. The NHIS cohort data includes all claims data; general health examination results, which are updated every 2 years; and health examination results specified for life-turning points, such as reaching the age of 40 or 66 years between 2002 and 2015. Subjects who were diagnosed with AD (N=1,489) or died (N=5,489) between 2002 and 2005 were excluded from the cohort sample. The study population comprised individuals who were diagnosed with SDB and those without SDB who were matched by using propensity score. The matched cohort was followed up until the onset of AD, death, or end of 2015. The study groups comprised the SDB group (N=727) and the control group (N=3,635). The SDB group comprised patients who were diagnosed with SDB between 2002 and 2005. On the other hand, subjects without SDB were randomly selected to form the control group. Subjects without SDB were matched to subjects with SDB at a ratio of 5:1 by sex, age, index date (the date of first diagnosis), CVD, hypertension, type 2 DM, depression, body mass index (BMI), smoking status, physical activity, and drinking by using propensity scoring and the stepwise algorithm. The matched cohort was followed up until onset of AD, death, or end of 2015. The cohort data included information on demographic characteristics, medical utilization, medical check-up, and health behavior. After PSM, the chisquare test was used to assess differences in the proportions between the SDB and control groups. To estimate the influence of SDB on AD onset, Kaplan–Meier survival curves and multivariate Cox proportional hazard models were used. Kaplan–Meier curves of the incidence of AD based on the presence of SDB showed differences. The log-rank test showed that the SDB group had a higher risk of AD than the non-SDB group (log-rank test p < 0.0422). After adjusting for the possible confounding variables, patients with SDB were almost 1.58 times more likely to develop AD than those without SDB. The present study showed that SDB was associated with an onset of AD. The findings of this study highlight the importance of the interventions to raise awareness of SDB and the need for the government's support to reduce the barrier in accessing appropriate SDB treatment.
Biography:
Amna Elgaali Dietitian Based in Qatar, she received her Honour Bachelor’s degree in Science in Dietetics from Ahfad university for women and completed her Dietetic Internship at Military Hospital- Omdurman., she also completed Nutrition & Health Course at UK open college. After working as a clinical dietitian for close to two years. Today, Amna uses her skills in nutrition and Diet therapy to run her practice in private sector, where she helps people to understand the relationship between the food and their bodies so they can show up for what matters most in their life, and improve their wellness.
Abstract:
There is no universally accepted definition of functional foods; however, there’s several organizations have defined this emerging food category. The International Food Information Council (IFIC) defines functional foods as foods that provide health benefits beyond basic nutrition. Health Canada defines it as “similar in appearance to a conventional food, but with benefits, and/or to reduce the risk of chronic disease beyond basic nutritional functions”. According to these definitions, unmodified whole foods such as fruits and vegetables represent the simplest form of a functional food. Africa has an abundant plant species which are known to be rich in health promoting compounds, many of which remain undiscovered or unused by the western society, Such as Guddaim, the chemical analysis and nutritional properties of this fruits investigationshowed this fruit contained a lot of important nutrients and nutritional value, beneficial to human health, Generally, the present study indicated that guddaim fruits possess good nutritional value, as they contains reasonable amount of iron this is explain why Sudanese population consume it to treat anaemia. Hibiscus also is used to treat high blood pressure. Gum Arabic, this generous plant has been reported to be used internally for the treatment of inflammation of the intestinal mucosa. Recently, a report from Sudan assessed that serum creatinine, urea, phosphate and uric acid concentrations were reported to be significantly reduced on the patients with Chronic Renal Failure on a low-protein diet. Baobab (Adansonia digitata L.) which provides a variety of important nutrients including vitamins, minerals and amino acids, and has many uses, such as medicine, food, and beverages, due to its content of rich in pectin and vitamin C. Further researches show potent nutritional value of traditional plant, such as Tamarind,
Doum, and okra.
Naheed Mojgani
Razi Vaccine and Serum Research Institute, Iran
Title: Synergistic antibacterial effect of probiotic lactic acid bacteria isolated from honey bees and propolis extracts on American and European foulbrood disease
Biography:
Naheed Mojgani has completed her PhD in Microbiology, is an Associate Professor at Razi Vaccine and Serum Research Institute (RVSRI), Iran. She is the Head of the Human and Animal Probiotic Research Lab at RVSRI and is a Senior Scientific Advisor at a probiotic manufacturing company (Biorun.Co Iran). She has commercialized several local probiotic isolates and also transferred the technology which she knows about probiotic supplement production. She has supervised several PhD and MSc students and has published more than 40 scientific papers and has presented her research work at several international and national conferences.
Abstract:
P larvae subsp. larvae, the agent of American foulbrood and Melissococcus plutonius, the agent of European foulbrood in honeybees are leading factors afflicting honey bee health and causing huge colony losses. To control this diseases antibiotics are used, which pose risks not only to honey bee health but is also a threat to humans. A number of biological controls methods are investigated in this regard for the control and prevention of these diseases. In this respect, probiotic lactic acid bacteria (LAB) are highly investigated. Propolis, a non-toxic wax like resinous substance found is bee hives is reported to be highly antibacterial and eco-friendly. In this study, we aimed to determine the synergistic antibacterial effect of probiotic lactic acid bacteria (LAB) isolated from honey bee (Apis mellifera) intestinal specimens, and different concentrations of ethanolic extracts of Propolis, against Paenibacillus larvae and Melissococcus plutonius. Initially, a number of LAB were isolated from honey bees by culturing the intestinal specimens on MRS and M17 media under aerobic and anaerobic conditions. The isolates were identified by biochemical and 16SrRNA sequencing. Four different concentrations of propolis collected from beehives of Alborz, Kurdistan and Tehran province, and the identified LAB isolates were tested for their antibacterial spectrum against Paenibacillus larvae and Melissococcus plutonius. Chlorhexidine (0.2%) and sterile saline were used as positive and negative control, respectively. The survival and growth of the L. casei TA0053, L. lactis NM00126, P. acidilactici TA0300 and E. faecium TA0312 (108 CFU/ml) in the presence of different propolis concentrations at different time intervals were investigated and their MIC determined. Synergistic effect of propolis and LAB bacterial strain against different cell concentrations of Paenibacillus larvae and Melissococcus plutonius was evaluated and their MIC recorded.
Madeleine Karlsson
Nutrition for Naughty People, Monaco
Title: The gut-brain connection: How what we eat affects our mental health?
Biography:
Madeleine Karlsson has completed her studies in Institute for Integrative Nutrition and is a certified Holistic Health and Nutrition Coach. In her work, she helps her clients mend their relationship with food, improve their physical and mental health; and optimize their weight by teaching how to eat intuitively. She is also an International Speaker, Corporate Consultant and Natural Food Chef.
Abstract:
Statement of the Problem: Mental health disorders are on the rise, from ADHD and anxiety to depression and dementia, the number of people who are suffering from the mental health issues is at an all-time high. In 2001, the World Health Organization predicted that one out of four people would be affected by a mental disorder at some point in their life. Today, antidepressants are some of the most popular drugs in the United States, and their usage shows no signs of waning. In Germany, antidepressant use has risen 46% in just four years. In Spain and Portugal, it rose about 20% during the same period.
Methodology & Theoretical Orientation: An inter subjective experiment instructing subjects to eliminate sugar and all processed foods, to eat a whole foods diet high in antioxidants and healthy fats over a period of three months. The subjects were also instructed to incorporate daily movement and to start practicing meditation as a form of relaxation and to reduce stress.
Findings: The subjects of the study reported an elevated mood within a few days to a couple of weeks. They also reported higher energy levels, better productivity, less brain fog and higher resistance to stress. Other results included better digestion, less bloating and weight loss between 1 to 6 kgs in the first four weeks. One subject was on mood stabilizing medication at the beginning of the study and was gradually coming off it
with the assistance of her psychiatrist at the end. She had been on medication for 10 years.
Conclusion & Significance: Our mental health is affected by our diet and more and more scientific evidence is emerging to confirm this. Stress and what we eat can alter the composition and products of the gut flora. Subjects who are transferred from a traditional Western diet that is high in trans-fat, additives and carbohydrates to a diet that is high in antioxidants, fiber and healthy fats change the composition of the
microbiota and as a result, their mental health improves.