H. O. T. Iyawe
Ambrose Alli University, Nigeria
Title: Antioxidant Potential and Histological Assessment of Crude Leaf Extract of Musa Paradisiaca L.
Biography
Biography: H. O. T. Iyawe
Abstract
M. paradisiaca L is a plant widely cultivated in the tropics and subtropical regions of the world for its carbohydrate food value. Most parts of the plant are used for medicinal purposes. There is a dearth of empirical information on the antioxidant values of the leaves. This study investigates the antioxidant power and examines the effect of aqueous and ethanol extracts of M. paradisiaca leave extracts on animals. Fifteen Wistar albino rats were used for the study, made up of three categories of five rats each as Control, and Test groups. Administrations of extracts were through intraperitoneal routes for 28 days. Results were obtained with standard procedures and indicated that Ethanol extracts to significantly (p<0.05) increase Nitric oxide (41. 66 ± 0.43%) and Hydrogen peroxide (13.04 ± 1.12%) inhibitions in comparison with aqueous extracts. Malondialdehyde (MDA) and Total Antioxidant Capacity (TAC) were also significantly (p<0.05) high in ethanol extract (0.76 ± 0.03 mmol/g) and (20.10 ± 1.29) respectively. Total phenolic and total flavonoids demonstrated better extraction in aqueous than in ethanol media. DPPH scavenging activity and reducing power assays were concentration dependent with aqueous extract showing better free radical scavenging ability and electron reduction power. Aqueous and Ethanol extracts significantly (p<0.05) reduced cholesterol, Triacylglyceride (TG) and High Density Lipoproteins (HDL-c). Ethanol extract treated group showed tissue sinusoids and hepatocytes with signs of necrosis. Deduction from this empirical evidence is that there is a latent antioxidant potentials in M. paradisiaca L which may be better harnessed from its aqueous extract.